ABSTRACT
SUMMARY. Covid-19 was announced as a pandemic in March 2020, since then scientists are trying to find out effective therapeutics as treatment. Many medicinal herbs contain antiviral compounds, such as rutin, and flavonoid glycosides that are efficient against viruses. Diplotaxis acris is a famous plant traditionally used to prepare rocket salad. LC-MS of methanol extract revealed the presence of 12 compounds, quercetin 3-O-β-rhamnoside, isorhamnetin 7-O-β-glucoside, kaempferol 3,7-diglucoside, apigenin 7-rhamnoside, and apigenin 7-O-β-glucoside as major compounds. The computational studies showed that all flavonoids form strong interaction with SARS-CoV-2 main protease with good CDOCKER interaction energy (Kcal/mol) of-53.1,-51.7,-44.1,-48.0, and-49.7, respectively, which are apigenin 7-rhamnoside as a suitable contender for oral administration. Results suggest that Diplotaxis acris have potential against SARS-CoV-2 and could be a good source of lead compounds against the novel coronavirus.